Inhibitory action of cholecystokinin on acid secretion from Heidenhain pouches induced by endogenous gastrin.

Kosaka and Lim (1930) demonstrated that extracts from the upper intestine would inhibit gastric secretion from dogs with Heidenhain pouches. The degree of inhibition produced was similar to that observed after the oral ingestion of fat. Similar doses of the extract were shown to have no effect on either pancreatic or biliary secretion. Gillespie and Grossman (1964) have demonstrated that cholecystokinin will inhibit acid secretion in Heidenhain pouches which has been induced by exogenous gastrin and histamine. The inhibitory effect was greater on exogenous gastrin-induced acid secretion than on histamine-induced acid secretion. The study reported here was undertaken to observe the effect of the Vitrum preparation of cholecystokinin-pancreozymin on acid secretion stimulated by release of endogenous gastrin. Endogenous gastrin was released from denervated antral pouches by perfusing with acetylcholine and peptone solutions. The acid secretion from Heidenhain pouches induced by the release of endogenous gastrin and the effect of cholecystokinin-pancreozymin extract on this acid secretion was observed.