Inhibitory action of cholecystokinin on acid secretion from Heidenhain pouches induced by endogenous gastrin.
نویسندگان
چکیده
Kosaka and Lim (1930) demonstrated that extracts from the upper intestine would inhibit gastric secretion from dogs with Heidenhain pouches. The degree of inhibition produced was similar to that observed after the oral ingestion of fat. Similar doses of the extract were shown to have no effect on either pancreatic or biliary secretion. Gillespie and Grossman (1964) have demonstrated that cholecystokinin will inhibit acid secretion in Heidenhain pouches which has been induced by exogenous gastrin and histamine. The inhibitory effect was greater on exogenous gastrin-induced acid secretion than on histamine-induced acid secretion. The study reported here was undertaken to observe the effect of the Vitrum preparation of cholecystokinin-pancreozymin on acid secretion stimulated by release of endogenous gastrin. Endogenous gastrin was released from denervated antral pouches by perfusing with acetylcholine and peptone solutions. The acid secretion from Heidenhain pouches induced by the release of endogenous gastrin and the effect of cholecystokinin-pancreozymin extract on this acid secretion was observed.
منابع مشابه
Inhibitory Effect of Secretin and Cholecystokinin on Heidenhain Pouch Responses to Gastrin Extract and Histamine.
Rapid intravenous injections of secretin and cholecystokinin (Vitrum) inhibited the acid response of Heidenhain pouch dogs to continuous intravenous gastrin extract. Cholecystokinin caused greater inhibition than secretin. Responses to small doses of histamine were inhibited by cholecystokinin but not by secretin.
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215 (4): 885-888. 1968.-The inhibitory effects of intravenous infusions of secretin and intraduodenal infusions of HCl on gastric secretion were compared in dogs having Heidenhain pouches, gastric and duodenal fistulas. With the gastric fistula open a constant level of secretion was established in the Heidenhain pouch with either gastrin (0.4 or 0.8 g/kg per hr) or histamine dihydrochloride (0....
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Relationship between serum gastrin levels and gastric secretion was studied in Heidenhain pouch dogs. Bethanecol and tetramethylammonium increased gastric secretion without any significant change in the serum immunoreactive gastrin (IRG) level. Histamine increased gastric secretion but decreased the serum IRG level. Tetragastrin evoked gastric secretion concomitantly with an elevation of the se...
متن کاملSecretin and cholecystokinin-pancreozymin in combination in the inhibition of gastric acid secretion.
Both secretin, and the single substance which possesses both cholecystokinin and pancreozymin activity, have been shown to inhibit gastric acid secretory responses. Since potentiation may occur between pairs of stimulants of gastric secretion, the effects of combining secretin and cholecystokinin/pancreozymin have been studied in Heidenhain pouches stimulated by continuous intravenous pentagast...
متن کاملPotentiation between Urecholine and Gastrin Extract and between Urecholine and Histamine in the Stimulations of Heidenhain Pouches.
It is frequently said that cholinergic activity, induced either by drugs or by vagal activity, 'potentiates' the acid secretory responses to gastrin or to histamine. The assumption that these combinations of stimuli act in a 'potentiated' rather than an 'additive' fashion is based upon the large augmentations that occur. So far as we have been able to determine, no previous study has provided d...
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عنوان ژورنال:
- Gut
دوره 8 1 شماره
صفحات -
تاریخ انتشار 1967